Silvia Zecchini Selected Research

climacostol

1/2019	The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents.
12/2018	Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells.
11/2016	Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on anti-tumour properties of ciliate bioactive molecules.
1/2016	Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme.

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Silvia Zecchini Research Topics

Disease

7	Neoplasms (Cancer) 09/2019 - 02/2008
6	Melanoma (Melanoma, Malignant) 11/2021 - 01/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 09/2019
1	Inflammation (Inflammations) 11/2021
1	Muscular Diseases (Myopathy) 02/2021
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021
1	Acidosis 01/2019
1	Thymoma (Thymic Carcinoma) 01/2019
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 12/2016
1	Peritoneal Fibrosis 04/2016
1	Ovarian Neoplasms (Ovarian Cancer) 08/2011
1	Carcinoma (Carcinomatosis) 02/2008
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2003

Drug/Important Bio-Agent (IBA)

4	climacostolIBA 01/2019 - 01/2016
3	EnzymesIBA 11/2021 - 05/2016
3	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2020 - 05/2016
3	AcidsIBA 01/2020 - 05/2016
2	CaspasesIBA 09/2019 - 01/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2019 - 01/2019
2	Biological ProductsIBA 01/2019 - 11/2016
2	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 05/2016
2	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA 08/2011 - 01/2010
1	Oxygen (Dioxygen)IBA 11/2021
1	NitrogenIBA 11/2021
1	Retinaldehyde (Retinal)IBA 02/2021
1	DystrophinIBA 02/2021
1	givinostatIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	X-Linked Inhibitor of Apoptosis ProteinIBA 09/2019
1	gibbilimbol BIBA 09/2019
1	CCAAT-Enhancer-Binding ProteinsIBA 01/2019
1	Kelch-Like ECH-Associated Protein 1IBA 01/2019
1	Insulin-Like PeptidesIBA 01/2019
1	AntigensIBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2019
1	Myosins (Myosin)IBA 01/2019
1	Growth Hormone (Somatotropin)IBA 01/2019
1	Cadherins (E-Cadherin)IBA 01/2019
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2019
1	Leukocyte Common Antigens (CD45 Antigen)IBA 01/2019
1	MyogeninIBA 01/2019
1	Platelet Endothelial Cell Adhesion Molecule-1IBA 01/2019
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2019
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 01/2019
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	fibroblast growth factor 21IBA 01/2019
1	CCAAT-Enhancer-Binding Protein-betaIBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Ribosomal Protein S6IBA 01/2019
1	CD11b AntigenIBA 01/2019
1	Prokaryotic Initiation Factor-2IBA 01/2019
1	PPAR gammaIBA 01/2019
1	Mitogen-Activated Protein Kinase 3IBA 01/2019
1	STAT5 Transcription FactorIBA 01/2019
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2019
1	CateninsIBA 01/2019
1	Activating Transcription Factor 4IBA 01/2019
1	Myogenic Regulatory Factor 5IBA 01/2019
1	Peptide Initiation Factors (Initiation Factor)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Somatotropin Receptors (Growth Hormone Receptor)IBA 01/2019
1	Qa-SNARE Proteins (Syntaxin)IBA 01/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	Serine (L-Serine)FDA Link 01/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018
1	nutlin 3IBA 01/2017
1	Histones (Histone)IBA 12/2016
1	euplotin CIBA 11/2016
1	Chloroquine (Aralen)FDA LinkGeneric 05/2016
1	SphingolipidsIBA 05/2016
1	Caspase 3 (Caspase-3)IBA 01/2016
1	Cytochromes c (Cytochrome c)IBA 01/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 02/2008
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 02/2008
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2003

Therapy/Procedure

3	Therapeutics 01/2017 - 01/2016
2	Drug Therapy (Chemotherapy) 01/2017 - 11/2016
1	Peritoneal Dialysis 04/2016
1	Injections 01/2016